Delayed chromosomal instability induced by DNA damage.
نویسندگان
چکیده
منابع مشابه
DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP
PhIP is an abundant heterocyclic aromatic amine (HCA) and important dietary carcinogen. Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guanine. Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication machinery and the elicited DNA damage response (DDR) have not yet been studied. Here, we analyzed PhIP-triggered replicative stre...
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The ATM/ATR DNA damage checkpoint functions in the maintenance of genetic stability and some missense variants of the ATM gene have been shown to confer a moderate increased risk of prostate cancer. However, whether inactivation of this checkpoint contributes directly to prostate specific cancer predisposition is still unknown. Here, we show that exposure of non-malignant prostate epithelial ce...
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Mutations in critical genes are believed to be a necessary part of cancer induction. The conventional view of radiation mutagenesis is that radiation induces most mutations in cells shortly after irradiation, because of false repair or lack of repair of DNA damage before or during DNA replication. In contrast, we here show that delayed mutations in the hypoxanthine phosphoribosyltransferase loc...
متن کاملChronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae.
Oxidative DNA damage is likely to be involved in the etiology of cancer and is thought to accelerate tumorigenesis via increased mutation rates. However, the majority of malignant cells acquire a specific type of genomic instability characterized by large-scale genomic rearrangements, referred to as chromosomal instability (CIN). The molecular mechanisms underlying CIN are not entirely understo...
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Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are selectively hypersensitive to DNA strand breaking agents, and that damage resistance requires th...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1993
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.13.11.6667